The 14 bp Del/Ins HLA-G Polymorphism Is Related with High Blood Pressure in Acute Coronary Syndrome and Type 2 Diabetes Mellitus

• Published in: BioMed research international Vol. 2014; no. 2014; pp. 1 - 8
• Main Authors: García-González, Ilian Janet, Valle, Yeminia, Rivas, Fernando, Figuera-Villanueva, Luis Eduardo, Muñoz-Valle, José Francisco, Flores-Salinas, Hector Enrique, Gutiérrez-Amavizca, Bianca Ethel, Dávalos-Rodríguez, Nory Omayra, Padilla-Gutiérrez, Jorge Ramón
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 01.01.2014; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Acute coronary syndrome; Acute Coronary Syndrome - genetics; Acute coronary syndromes; Aged; Base Pairing - genetics; Cardiovascular disease; Case-Control Studies; Chronic illnesses; Confidence intervals; Demography; Development and progression; Diabetes; Diabetes Mellitus, Type 2 - genetics; Drug therapy; Female; Gene Frequency - genetics; Genetic aspects; Genetic Association Studies; Genetic polymorphisms; Genetic Predisposition to Disease; Health aspects; Heart attacks; Histocompatibility antigens; HLA histocompatibility antigens; HLA-G Antigens - genetics; Humans; Hypertension; Hypertension - genetics; INDEL Mutation - genetics; Inflammatory diseases; Ischemia; Male; Models, Genetic; Mortality; Polymorphism; Preeclampsia; Studies; Type 2 diabetes
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2014/898159

Immunologic and inflammatory processes are involved in the pathogenesis of acute coronary syndrome (ACS) and type 2 diabetes mellitus (DM2). Human leukocyte antigen-G (HLA-G) is a negative regulator of the immune response. This study evaluates the 14 bp Del/Ins HLA-G polymorphism in ACS and DM2. Three hundred and seventy individuals from Western Mexico were recruited and categorized into three groups: ACS (86), DM2 without coronary complications (70), and healthy subjects (214). Genotyping of the 14 bp Del/Ins HLA-G polymorphism was performed by PCR and Native-PAGE. The most common risk factors were hypertension and overweight in ACS and DM2, respectively. The genetic distribution of the 14 bp Del/Ins HLA-G polymorphism showed no significant differences between groups (P≥0.23). Nonetheless, the Ins/Ins genotype was associated with high blood pressure (HBP) in the DM2 group (ORc = 1.65, P=0.02). The genetic recessive model showed similar findings (ORc = 3.03, P=0.04). No association was found in ACS, with a P of 0.05; nevertheless, the prevalence of Ins/Ins carriers was quite similar to that found in the DM2-HBP group. The 14 bp Del/Ins HLA-G polymorphism was not a susceptibility factor for ACS or DM2; however, the Ins/Ins genotype might have contributed to the development of HBP in the studied groups.