Morphological Changes in the Suprachiasmatic Nucleus of Aging Female Marmosets (Callithrix jacchus)

The suprachiasmatic nuclei (SCN) are pointed to as the mammals central circadian pacemaker. Aged animals show internal time disruption possibly caused by morphological and neurochemical changes in SCN components. Some studies reported changes of neuronal cells and neuroglia in the SCN of rats and no...

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Published inBioMed research international Vol. 2014; no. 2014; pp. 1 - 10
Main Authors Cavalcante, Judney C., Costa, Miriam Stela M. O., Cavalcante, Jeferson S., Engelberth, Rovena Clara G. J., Nascimento Junior, Expedito S., Soares, Joacil Germano, Santos, Jose Ronaldo dos, Silva, Kayo Diogenes de A., Azevedo, Carolina V. de M., Gavioli, Elaine Cristina
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Puplishing Corporation 01.01.2014
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Aging
Aging - physiology
Animals
Behavior
Callithrix
Callithrix jacchus
Circadian rhythm
Circadian Rhythm - physiology
Female
Health aspects
Laboratories
Male
Marmosets
Morphology (Animals)
Nervous system
Neurodegeneration
Neurons
Primates
Proteins
Rats
Studies
Suprachiasmatic nucleus
Suprachiasmatic Nucleus - cytology
Suprachiasmatic Nucleus - growth & development
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Summary:The suprachiasmatic nuclei (SCN) are pointed to as the mammals central circadian pacemaker. Aged animals show internal time disruption possibly caused by morphological and neurochemical changes in SCN components. Some studies reported changes of neuronal cells and neuroglia in the SCN of rats and nonhuman primates during aging. The effects of senescence on morphological aspects in SCN are important for understanding some alterations in biological rhythms expression. Therefore, our aim was to perform a comparative study of the morphological aspects of SCN in adult and aged female marmoset. Morphometric analysis of SCN was performed using Nissl staining, NeuN-IR, GFAP-IR, and CB-IR. A significant decrease in the SCN cells staining with Nissl, NeuN, and CB were observed in aged female marmosets compared to adults, while a significant increase in glial cells was found in aged marmosets, thus suggesting compensatory process due to neuronal loss evoked by aging.
Bibliography:ObjectType-Article-1
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Academic Editor: Estela Muñoz
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/243825