MicroRNAs as Regulators of Differentiation and Cell Fate Decisions

Unique expression domains, targets, and gain- and loss-of-function phenotypes of particular microRNAs have important implications for directed differentiation of stem cell populations and suppression of undesired cell types. We discuss this emerging topic, in part using muscle differentiation as a p...

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Bibliographic Details
Published inCell stem cell Vol. 7; no. 1; pp. 36 - 41
Main Authors Ivey, Kathryn N., Srivastava, Deepak
Format Journal Article
LanguageEnglish
Published Cambridge, MA Elsevier Inc 02.07.2010
Cell Press
Subjects
Animals
Biological and medical sciences
Cell Cycle - genetics
Cell Cycle - physiology
Cell Differentiation - genetics
Cell Differentiation - physiology
Cell differentiation, maturation, development, hematopoiesis
Cell Lineage - genetics
Cell Lineage - physiology
Cell physiology
Embryonic Stem Cells - cytology
Embryonic Stem Cells - metabolism
Fundamental and applied biological sciences. Psychology
Humans
MicroRNAs - genetics
MicroRNAs - metabolism
Models, Biological
Molecular and cellular biology
Gene silencing
RNA interference
Cell differentiation
Micro RNA
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Summary:Unique expression domains, targets, and gain- and loss-of-function phenotypes of particular microRNAs have important implications for directed differentiation of stem cell populations and suppression of undesired cell types. We discuss this emerging topic, in part using muscle differentiation as a paradigm, and highlight common themes and unique modalities by which microRNAs exert their lineage-promoting or differentiation effects on multiple tissues.
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ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2010.06.012