Oxidative stress, oxidative balance score, and hypertension among a racially diverse population

Abstract Hypertension is a risk factor for several vascular diseases. Evidence suggests that oxidative stress (OS) plays a significant role in its pathophysiology. Human studies have shown inconsistent results, varying based on the OS biomarker and study population. In a racially diverse population,...

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Published inJournal of the American Society of Hypertension Vol. 9; no. 8; pp. 592 - 599
Main Authors Annor, Francis B., MPH, PhD, Goodman, Michael, MD, MPH, Okosun, Ike S., MS, MPH, PhD, FRSPH, FTOS, Wilmot, Douglas W., PhD, Il'yasova, Dora, PhD, Ndirangu, Murugi, PhD, Lakkur, Sindhu, PhD
Format Journal Article
LanguageEnglish
Published United States 01.08.2015
Subjects
Adult
Aged
Antioxidants - metabolism
Biomarkers - blood
Blood Pressure - physiology
Cardiovascular
Continental Population Groups
Cross-Sectional Studies
Feasibility Studies
Female
Follow-Up Studies
Gas Chromatography-Mass Spectrometry
Georgia - epidemiology
Humans
Hypertension - blood
Hypertension - ethnology
Hypertension - physiopathology
Male
Middle Aged
Oxidative Stress - physiology
Prevalence
Reactive Oxygen Species - blood
Risk Factors
Georgia
Antioxidants
blood pressure
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Summary:Abstract Hypertension is a risk factor for several vascular diseases. Evidence suggests that oxidative stress (OS) plays a significant role in its pathophysiology. Human studies have shown inconsistent results, varying based on the OS biomarker and study population. In a racially diverse population, examine the association between: (1) blood pressure or hypertension and four markers of OS and (2) blood pressure or hypertension and oxidative balance score (OBS). Using data (n = 317) from the cross-sectional study on race, stress, and hypertension, an OBS was constructed from various measures of pro-oxidant and antioxidant exposures. OS was assessed by four biomarkers: fluorescence oxidative products, F2 -isoprostanes, mitochondrial DNA copy number, and gamma tocopherol. Multivariate linear and logistic regression analyses were used to estimate the associations of interest. None of the adjusted associations between hypertension and OS markers was statistically significant. OBS was inversely associated with hypertension after adjusting for study covariates. Persons with higher OBS have lower odds of having hypertension; however, the evidence on the relationship between OS markers and blood pressure remains unconvincing.
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ISSN:1933-1711
1878-7436
DOI:10.1016/j.jash.2015.05.014