Prooxidant properties of ascorbic acid in the nigrostriatal dopaminergic system of C57BL/6 mice

• Published in: Toxicology (Amsterdam) Vol. 294; no. 1; pp. 1 - 8
• Main Authors: Kang, Min Jeong, Lee, Sang Sun, Koh, Hyun Chul
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ireland Ltd 29.03.2012; Elsevier
• Subjects: 3,4-Dihydroxyphenylacetic Acid - analysis; aerobiosis; Animals; antioxidants; Ascorbic acid; Ascorbic Acid - pharmacology; Biological and medical sciences; Corpus Striatum - chemistry; Corpus Striatum - drug effects; Corpus Striatum - metabolism; Dopamine; Dopamine - analysis; Dopaminergic Neurons - drug effects; Emergency; Glutathione; Glutathione - analysis; Male; Medical sciences; metabolites; Mice; Mice, Inbred C57BL; neurotoxicity; Oxidants - pharmacology; oxidation; Oxidation-Reduction - drug effects; oxidative stress; reducing agents; Striatum; Substantia Nigra - chemistry; Substantia Nigra - drug effects; Substantia Nigra - metabolism; Substantia nigra pars compacta; Toxicology; tyrosine; Tyrosine 3-Monooxygenase - metabolism; Striatum; Ascorbic acid; Dopamine; Substantia nigra pars compacta; Glutathione; Enzyme; Transferases; Glycosyltransferases; Rodentia; Central nervous system; Vitamin; Basal ganglion; Corpus striatum; Catecholamine; Encephalon; NAD; Vertebrata; Mammalia; Locus niger; Mouse; Animal; Neurotransmitter; ADP-ribosyltransferase; Pentosyltransferases
• ISSN: 0300-483X; 1879-3185
• DOI: 10.1016/j.tox.2012.01.007

Highlights ► Ascorbic acid induces dopaminergic neurotoxicity. ► ROS is involved in ascorbic acid-mediated cell death. ► GSH is involved in ascorbic acid toxicity.