Pretreatmet with 5% lidocaine patch reduces cannula-induced and propofol-induced pain: a randomized, double-blind, placebo-controlled study

• Published in: Korean journal of anesthesiology Vol. 69; no. 5; pp. 468 - 473
• Main Authors: Hong, Jung-Min, Lee, Hyeon Jeong, Cho, Ah Reum, Baik, Ji Seok, Lee, Do Won, Ji, Young Tae, Yoo, Ki Chan, Kim, Hae-Kyu
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Anesthesiologists 01.10.2016; Korean Society of Anesthesiologists; 대한마취통증의학회
• Subjects: Clinical; cutaneous administration; lidocaine; pain; propofol; 마취과학; Pain; Propofol; Cutaneous administration; Lidocaine
• ISSN: 2005-6419; 2005-7563
• DOI: 10.4097/kjae.2016.69.5.468

The purpose of this study was to determine the efficacy of 5% lidocaine patch in reducing propofol-induced pain and cannula-induced pain. In a randomized, double-blind study, 126 patients were divided into one of three groups: pretreatment with a 5% lidocaine patch (Lidotop®) and premixed 2 ml of normal saline with 1.5 mg/kg of 1% propofol (Group A); pretreatment with a placebo patch and premixed 2 ml of normal saline with 1.5 mg/kg of 1% propofol (Group B); or pretreatment with a placebo patch and premixed 2 ml of 2% lidocaine (40 mg) with 1.5 mg/kg of 1% propofol (Group C) for induction of anesthesia. Pain severity was evaluated on a four-point verbal rating scale during intravenous cannulation, propofol injection, and 24 h after the operation (recall). Eighteen patients (47.4%) in Group A complained of cannula-induced pain compared with 35 (94.6%) in Group B and 36 (94.7%) in Group C (P < 0.001). Group A patients showed significantly lower incidence of propofol-induced pain and recall of propofol-induced pain compared with Group B (P < 0.001 and P = 0.01), whereas there was no difference compared with Group C. Preoperative transdermal administration of 5% lidocaine patch is an effective and simple method in reducing propofol-induced pain as well as cannula-induced pain.