Polysaccharide (ANK-102) from Polianthes tuberosa cells deteriorates the resistance of mice to Listeria monocytogenes infection

Modulatory effect on the murine self defense system by a newly discovered acidic polysaccharide (ANK-102) produced by P. tuberosa cells in liquid culture was examined. Pretreatment with ANK-102 deteriorated the murine survival against lethal infection of Listeria monocytogenes, an intracellular gram...

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Bibliographic Details
Published inImmunopharmacology and immunotoxicology Vol. 17; no. 1; p. 59
Main Authors Majima, T, Otsuji, K, Nagatomi, R, Konno, T
Format Journal Article
LanguageEnglish
Published England 01.01.1995
Subjects
Animals
Bacteriological Techniques
Immunity, Innate - drug effects
Immunosuppressive Agents - toxicity
Lentinan - toxicity
Listeria monocytogenes - drug effects
Listeria monocytogenes - growth & development
Listeriosis - immunology
Male
Mice
Mice, Inbred C3H
Polysaccharides - toxicity
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Summary:Modulatory effect on the murine self defense system by a newly discovered acidic polysaccharide (ANK-102) produced by P. tuberosa cells in liquid culture was examined. Pretreatment with ANK-102 deteriorated the murine survival against lethal infection of Listeria monocytogenes, an intracellular gram-positive bacterium eliminated mainly by macrophages through T-cell mediated immune response. Pretreatment with ANK-102 resulted in the accumulation of Mac 1 and Mac 2 positive cells in the peritoneal cavity of the infected animals and the reduction of Thy1.2 expression on the surface of the thymocytes. A new type of immunosuppressive polysaccharide ANK-102 was introduced.
ISSN:0892-3973
DOI:10.3109/08923979509052720