Distal Renal Tubular Acidosis that Became Exacerbated by Proton Pump Inhibitor Use

• Published in: Internal Medicine Vol. 51; no. 18; pp. 2591 - 2595
• Main Authors: Okamoto, Natsumi, Nambu, Takuo, Matsuda, Yuki, Matsuo, Koji, Osaki, Keisuke, Kanai, Yugo, Ogawa, Yoshihisa, Yonemitsu, Shin, Kita, Ryuichi, Muro, Seiji, Sugawara, Akira, Oki, Shogo
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2012
• Subjects: Acidosis, Renal Tubular - chemically induced; Acidosis, Renal Tubular - diagnosis; distal renal tubular acidosis; Female; Gastroesophageal Reflux - drug therapy; H(+)-K(+)-Exchanging ATPase - drug effects; Homeostasis - drug effects; Humans; Hydrogen - metabolism; hypokalemia; Hypokalemia - chemically induced; Hypokalemia - diagnosis; Kidney - metabolism; metabolic acidosis; Middle Aged; Potassium - metabolism; proton pump inhibitor; Proton Pump Inhibitors - adverse effects; Proton Pump Inhibitors - pharmacology; Proton Pump Inhibitors - therapeutic use
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.51.7981

Acid-base imbalances and electrolyte disorders induced by proton pump inhibitors (PPIs) are extremely rare. However, under certain conditions, PPIs may cause metabolic acidosis or hypokalemia, probably due to an inhibitory action on the proton pump that contributes to H+ and K+ homeostasis in the kidney. We herein present a case of marked hypokalemia accompanied by distal renal tubular acidosis in which a PPI appeared to contribute to the pathophysiology of metabolic acidosis.