Synthesis of Non-Steroidal Estrogen Receptor Antagonists R1128 A, B, C, and D via an Oxazoline-Promoted Iterative ortho-Lithiation Strategy

A concise total synthesis of non-steroidal estrogen receptor antagonists R1128 A–D (1a–1d) has been achieved using iterative ortho-lithiation of 2-(4-methoxyphenyl)-4,4-dimethyloxazoline (3) as the key reaction.

Saved in:
Bibliographic Details
Published inBulletin of the Chemical Society of Japan Vol. 85; no. 1; pp. 133 - 135
Main Authors Fukuda, Tsutomu, Fukushima, Koichiro, Sanai, Susumu, Iwao, Masatomo
Format Journal Article
LanguageEnglish
Published TOKYO The Chemical Society of Japan 2012
Chemical Soc Japan
Chemical Society of Japan
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
SUBSTANCES
N,N-DIETHYLBENZAMIDES
STREPTOMYCES
DIRECTED METALATION
CANCER
Online AccessGet full text

Cover

More Information
Summary:A concise total synthesis of non-steroidal estrogen receptor antagonists R1128 A–D (1a–1d) has been achieved using iterative ortho-lithiation of 2-(4-methoxyphenyl)-4,4-dimethyloxazoline (3) as the key reaction.
Bibliography:KAKEN
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.20110243