Multifocal Fibrosclerosis with Hypertrophic Pachymeningitis and a Soft Tissue Mass around the Thoracic Vertebral Bodies: A Case Report with Review of the Literature

Multifocal fibrosclerosis is the term used to represent a combination of similar fibrous lesions occurring at different anatomical sites. We herein report a hypertrophic pachymeningitis patient with a soft tissue mass around the thoracic vertebral bodies. A histopathological analysis of the biopsied...

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Bibliographic Details
Published inInternal Medicine Vol. 54; no. 17; pp. 2267 - 2272
Main Authors Sato, Mitsuto, Kodaira, Minori, Ishii, Wataru, Nakagawa, Michitaka, Kishida, Dai, Miyazaki, Daigo, Shimojima, Yasuhiro, Matsuda, Masayuki, Uehara, Takeshi, Ikeda, Shu-ichi
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.01.2015
Subjects
a soft tissue mass around thoracic vertebral bodies
Aged
Anti-Inflammatory Agents - therapeutic use
granulomatosis with polyangiitis
Humans
hypertrophic pachymeningitis
Hypertrophy - diagnosis
IgG4-related disease
Immunosuppressive Agents - therapeutic use
Male
Meningitis - complications
Meningitis - diagnosis
Meningitis - drug therapy
Meningitis - pathology
Methylprednisolone - therapeutic use
multifocal fibrosclerosis
Plasma Cells - pathology
Retroperitoneal Fibrosis - complications
Retroperitoneal Fibrosis - congenital
Retroperitoneal Fibrosis - diagnosis
Retroperitoneal Fibrosis - drug therapy
Retroperitoneal Fibrosis - pathology
Tacrolimus - therapeutic use
Thoracic Vertebrae - pathology
Treatment Outcome
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Summary:Multifocal fibrosclerosis is the term used to represent a combination of similar fibrous lesions occurring at different anatomical sites. We herein report a hypertrophic pachymeningitis patient with a soft tissue mass around the thoracic vertebral bodies. A histopathological analysis of the biopsied tissues from both lesions showed dense fibrosis and a marked infiltration of lymphocytes and plasma cells, which lead to the diagnosis of multifocal fibrosclerosis. This pathological condition closely resembles that of IgG4-related disease and is a very rare combination of manifestations. Our case suggests that hypertrophic pachymeningitis patients need to also undergo a whole body examination.
Bibliography:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Review-1
ObjectType-Feature-5
ObjectType-Report-2
ObjectType-Article-4
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.54.3230