Effect of Duplicate Genes on Mouse Genetic Robustness : An Update

In contrast to S. cerevisiae and C. elegans, analyses based on the current knockout (KO) mouse phenotypes led to the conclusion that duplicate genes had almost no role in mouse genetic robustness. It has been suggested that the bias of mouse KO database toward ancient duplicates may possibly cause t...

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Published inBioMed research international Vol. 2014; no. 2014; pp. 1 - 13
Main Authors Su, Zhixi, Wang, Junqiang, Gu, Xun
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Puplishing Corporation 01.01.2014
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Age
Aging - genetics
Animals
Base Sequence
Chickens
Conserved Sequence - genetics
Evolution, Molecular
Gene amplification
Gene Duplication
Genes
Genes, Developmental
Genes, Duplicate
Genes, Essential
Genetic aspects
Genetic engineering
Genetic research
Genome - genetics
Genomes
Humans
Hypotheses
Laboratories
Mammals
Mice
Mice, Knockout
Models, Genetic
Proteins
Proteins - metabolism
Rodents
Studies
Time Factors
Zebrafish - genetics
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Summary:In contrast to S. cerevisiae and C. elegans, analyses based on the current knockout (KO) mouse phenotypes led to the conclusion that duplicate genes had almost no role in mouse genetic robustness. It has been suggested that the bias of mouse KO database toward ancient duplicates may possibly cause this knockout duplicate puzzle, that is, a very similar proportion of essential genes (PE) between duplicate genes and singletons. In this paper, we conducted an extensive and careful analysis for the mouse KO phenotype data and corroborated a strong effect of duplicate genes on mouse genetics robustness. Moreover, the effect of duplicate genes on mouse genetic robustness is duplication-age dependent, which holds after ruling out the potential confounding effect from coding-sequence conservation, protein-protein connectivity, functional bias, or the bias of duplicates generated by whole genome duplication (WGD). Our findings suggest that two factors, the sampling bias toward ancient duplicates and very ancient duplicates with a proportion of essential genes higher than that of singletons, have caused the mouse knockout duplicate puzzle; meanwhile, the effect of genetic buffering may be correlated with sequence conservation as well as protein-protein interactivity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Academic Editor: Leng Han
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/758672