Preparation, Characterization, and Release Kinetics of Chitosan-Coated Nanoliposomes Encapsulating Curcumin in Simulated Environments

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 10; p. 2023
• Main Authors: Hasan, Mahmoud, Elkhoury, Kamil, Kahn, Cyril J F, Arab-Tehrany, Elmira, Linder, Michel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.05.2019; MDPI
• Subjects: Animals; Antioxidants; Bioavailability; Biocompatibility; Biological properties; Carcinogens; Chitosan; Chitosan - chemistry; Coatings; Curcumin; Curcumin - pharmacology; Drug delivery systems; Drug Liberation; Efficiency; Encapsulation; Fatty acids; Fatty Acids - analysis; Food and Nutrition; gastrointestinal environment; Inflammation; Kinetics; Life Sciences; Lipids; Lipophilic; Liposomes; nanoliposomes; Nanoparticles; Nanoparticles - chemistry; Particle size; Physiology; Polymers; release kinetics; Salmon; Simulation; Systems analysis; chitosan; release kinetics; gastrointestinal environment; curcumin; nanoliposomes
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules24102023

Curcumin, a natural polyphenol, has many biological properties, such as anti-inflammatory, antioxidant, and anti-carcinogenic properties, yet, its sensitivity to light, oxygen, and heat, and its low solubility in water renders its preservation and bioavailability challenging. To increase its bioaccessibility, we fabricated nanoliposomes and chitosan-coated nanoliposomes encapsulating curcumin, and we evaluated the systems in terms of their physicochemical characteristics and release profiles in simulated gastrointestinal mediums. Chitosan-coating enhanced the stability of nanoliposomes and slowed the release of curcumin in the simulated gastrointestinal (GI) environment. This study demonstrates that nanoliposomes and chitosan-coated nanoliposomes are promising carriers for poorly soluble lipophilic compounds with low oral bioavailability, such as curcumin.