Feature-Based Molecular Networks Identification of Bioactive Metabolites from Three Plants of the Polynesian Cosmetopoeia Targeting the Dermal Papilla Cells of the Hair Cycle

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 1; p. 105
• Main Authors: Hughes, Kristelle, Ho, Raimana, Greff, Stéphane, Herbette, Gaëtan, Filaire, Edith, Ranouille, Edwige, Berthon, Jean-Yves, Raharivelomanana, Phila
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2022; MDPI
• Subjects: Acids; Bidens pilosa; Bioactive compounds; Bioassays; Biological activity; Calophyllum inophyllum; Cell growth; Cell proliferation; Cell Proliferation - drug effects; Cells, Cultured; Chemical Fractionation; Chromatography, High Pressure Liquid; Correlation coefficient; Correlation coefficients; Cosmetics; cosmetopoeia; Elongation; Epithelial cells; Epithelium; Fagraea berteroana; Flavonoids; Flavonols; Flowers & plants; Hair; Hair Follicle - cytology; hair growth; Humans; Life Sciences; Metabolites; metabolomics; Models, Theoretical; Molecular Structure; Natural products; Phenolic acids; Phenols; Phytochemicals - chemistry; Phytochemicals - isolation & purification; Phytochemicals - pharmacology; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Leaves - chemistry; Plant species; Plants, Medicinal - chemistry; Skin; Structure-Activity Relationship; Tandem Mass Spectrometry; United States > US; Calophyllum inophyllum; Fagraea berteroana; cosmetopoeia; hair growth; metabolomics; Bidens pilosa
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27010105

The term cosmetopoeia refers to the use of plants in folks' cosmetics. The aerial parts of L., the leaves of L. and the fruits of A.Gray ex Benth are traditionally used in French Polynesia for hair and skin care. During the hair cycle, dermal papilla cells and their interaction with epithelial cells are essential to promote hair follicle elongation. The aim of our investigations was the identification of metabolites from these three plants and chemical families responsible for their hair growth activity. A bioactivity-based molecular network was produced by mapping the correlation between features obtained from LC-MS/MS data and dermal papilla cell proliferation, using the Pearson correlation coefficient. The analyses pointed out glycosylated flavonols and phenolic acids from and , along with C-flavonoids, iridoids and secoiridoids from , as potential bioactive molecules involved in the proliferation of hair follicle dermal papilla cells. Our results highlight the metabolites of the plant species potentially involved in the induction of hair follicle growth and support the traditional uses of these plants in hair care.