Ontogenetic role of angiontensin-converting enzyme in rats: Thirst and sodium appetite evaluation

• Published in: Physiology & behavior Vol. 99; no. 1; pp. 118 - 124
• Main Authors: Mecawi, André S, Araujo, Iracema G, Rocha, Fábio F, Coimbra, Terezila M, Antunes-Rodrigues, José, Reis, Luís C
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 12.01.2010; Elsevier
• Subjects: Adrenergic beta-Agonists - pharmacology; Analysis of Variance; Angiotensin converting enzyme; Angiotensin I - pharmacology; Angiotensin II - pharmacology; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Animals; Animals, Newborn; Appetite - drug effects; Appetite - physiology; Behavioral psychophysiology; Biological and medical sciences; Blood Pressure - drug effects; Body Weight - drug effects; Captopril; Captopril - pharmacology; Dehydration - pathology; Dehydration - physiopathology; Diuretics, Osmotic - pharmacology; Drinking - drug effects; Drinking - physiology; Female; Fundamental and applied biological sciences. Psychology; Heart Rate - drug effects; Hydromineral balance; Injections, Intraventricular - methods; Isoproterenol - pharmacology; Kidney - cytology; Kidney - drug effects; Lactation - drug effects; Male; Ontogeny; Peptidyl-Dipeptidase A - metabolism; Perinatal period; Pregnancy; Pregnancy Outcome; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - pathology; Prenatal Exposure Delayed Effects - physiopathology; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Wistar; Renin–angiotensin system; Sodium appetite; Sodium Chloride - urine; Sodium, Dietary - pharmacology; Thirst; Thirst - drug effects; Thirst - physiology; Time Factors; Water-Electrolyte Balance - drug effects; Renin–angiotensin system; Perinatal period; Sodium appetite; Captopril; Angiotensin converting enzyme; Ontogeny; Hydromineral balance; Thirst; Rat; Peptidyl-dipeptidase A; Appetite; Evaluation; Enzyme; Rodentia; Enzyme inhibitor; Perinatal; Renin-angiotensin system; Peptidases; Vertebrata; Renin angiotensin system; Mammalia; Sodium; Animal; Hydrolases; Peptidyl-dipeptidases; Antihypertensive agent; ACE inhibitor
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/j.physbeh.2009.10.018

Abstract We investigated the influence of captopril (an angiotensin converting enzyme inhibitor) treatment during pregnancy and lactation period on hydromineral balance of the male adult offspring, particularly, concerning thirst and sodium appetite. We did not observe significant alterations in basal hydromineral (water intake, 0.3 M NaCl intake, volume and sodium urinary concentration) or cardiovascular parameters in adult male rats perinatally treated with captopril compared to controls. However, male offspring rats that perinatally exposed to captopril showed a significant attenuation in water intake induced by osmotic stimulation, extracellular dehydration and beta-adrenergic stimulation. Moreover, captopril treatment during perinatal period decreased the salt appetite induced by sodium depletion. This treatment also attenuated thirst and sodium appetite aroused during inhibition of peripheral angiotensin II generation raised by low concentration of captopril in the adult offspring. Interestingly, perinatal exposure to captopril did not alter water or salt intake induced by i.c.v. administration of angiotensin I or angiotensin II. These results showed that chronic inhibition of angiotensin converting enzyme during pregnancy and lactation modifies the regulation of induced thirst and sodium appetite in adulthood.