Mitochondria removal by autophagy

Mitochondrial dysfunction has severe cellular consequences and is linked with neurodegenerative diseases and aging. Maintaining a healthy population of mitochondria is thus essential for proper cellular homeostasis. Several strategies have evolved to prevent and limit mitochondria damage, and macroa...

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Bibliographic Details
Published inAutophagy Vol. 7; no. 3; pp. 297 - 300
Main Authors Wang, Ke, Klionsky, Daniel J
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.03.2011
Landes Bioscience
Subjects
Amino Acid Sequence
Animals
Autophagy
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Humans
Landes
Mitochondria - metabolism
Mitochondrial Proteins - chemistry
Mitochondrial Proteins - metabolism
Models, Biological
Molecular Sequence Data
Organogenesis
Proteins
Review
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Summary:Mitochondrial dysfunction has severe cellular consequences and is linked with neurodegenerative diseases and aging. Maintaining a healthy population of mitochondria is thus essential for proper cellular homeostasis. Several strategies have evolved to prevent and limit mitochondria damage, and macroautophagy plays a role in degrading superfluous or severely damaged mitochondria. Selective removal of mitochondria by autophagy (termed mitophagy) has been extensively studied recently in both yeast and mammalian cells. In this review, we summarize our current knowledge of mitophagy. We also compare the molecular process of mitophagy with other types of specific autophagic pathways and discuss its biological importance.
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ISSN:1554-8627
1554-8635
DOI:10.4161/auto.7.3.14502