Mixing of Pharmaceutical Powders examined by Use of Colored Particles : Discussions on Coloration Difference
A new mixing index based on Hunter's color difference formula was applied to the three-component mixing of antipyrin, lactose and lactose colored with pigment (tracer powder of antipyrin). The mixing was conducted in a twin-shell mixer. The scale of scrutiny of this index was comparable with th...
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| Published in | Chemical & pharmaceutical bulletin Vol. 22; no. 12; pp. 2803 - 2811 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
The Pharmaceutical Society of Japan
01.01.1974
公益社団法人日本薬学会 |
| Online Access | Get full text |
| ISSN | 0009-2363 1347-5223 |
| DOI | 10.1248/cpb.22.2803 |
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| Abstract | A new mixing index based on Hunter's color difference formula was applied to the three-component mixing of antipyrin, lactose and lactose colored with pigment (tracer powder of antipyrin). The mixing was conducted in a twin-shell mixer. The scale of scrutiny of this index was comparable with that of the mixing index used for the active ingredient. The concept of the uneven coloration is useful to follow the progress of mixing and to confirm the complete mixing. The relationship between the behavior of the active ingredient and tracer powder in the earlier stages of mixing was examined by the separate determination of antipyrin and pigment. |
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| AbstractList | A new mixing index based on Hunter's color difference formula was applied to the three-component mixing of antipyrin, lactose and lactose colored with pigment (tracer powder of antipyrin). The mixing was conducted in a twin-shell mixer. The scale of scrutiny of this index was comparable with that of the mixing index used for the active ingredient. The concept of the uneven coloration is useful to follow the progress of mixing and to confirm the complete mixing. The relationship between the behavior of the active ingredient and tracer powder in the earlier stages of mixing was examined by the separate determination of antipyrin and pigment. |
| Author | SHIROMOTO, SUMIKO TAKEDA, YOHKO HAYASHI, SHINICHI MATSUDA, YOSHIHISA OKADA, JUTARO |
| Author_FL | MATSUDA YOSHIHISA HAYASHI SHINICHI SHIROMOTO SUMIKO TAKEDA YOHKO OKADA JUTARO |
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| CitedBy_id | crossref_primary_10_1016_j_powtec_2016_12_053 crossref_primary_10_1246_bcsj_52_1034 crossref_primary_10_1016_S0032_5910_96_03178_6 |
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| Title | Mixing of Pharmaceutical Powders examined by Use of Colored Particles : Discussions on Coloration Difference |
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