Mixing of Pharmaceutical Powders examined by Use of Colored Particles : Discussions on Coloration Difference

A new mixing index based on Hunter's color difference formula was applied to the three-component mixing of antipyrin, lactose and lactose colored with pigment (tracer powder of antipyrin). The mixing was conducted in a twin-shell mixer. The scale of scrutiny of this index was comparable with th...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 22; no. 12; pp. 2803 - 2811
Main Authors TAKEDA, YOHKO, OKADA, JUTARO, SHIROMOTO, SUMIKO, MATSUDA, YOSHIHISA, HAYASHI, SHINICHI
Format Journal Article
LanguageEnglish
Published The Pharmaceutical Society of Japan 01.01.1974
公益社団法人日本薬学会
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ISSN0009-2363
1347-5223
DOI10.1248/cpb.22.2803

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Summary:A new mixing index based on Hunter's color difference formula was applied to the three-component mixing of antipyrin, lactose and lactose colored with pigment (tracer powder of antipyrin). The mixing was conducted in a twin-shell mixer. The scale of scrutiny of this index was comparable with that of the mixing index used for the active ingredient. The concept of the uneven coloration is useful to follow the progress of mixing and to confirm the complete mixing. The relationship between the behavior of the active ingredient and tracer powder in the earlier stages of mixing was examined by the separate determination of antipyrin and pigment.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.22.2803