Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors

• Published in: Endocrine Journal Vol. 63; no. 4; pp. 397 - 404
• Main Authors: Kondo, Takeshi, Endo, Itsuro, Aihara, Ken-ichi, Onishi, Yukiyo, Dong, Bingzi, Ohguro, Yukari, Kurahashi, Kiyoe, Yoshida, Sumiko, Fujinaka, Yuichi, Kuroda, Akio, Matsuhisa, Munehide, Fukumoto, Seiji, Matsumoto, Toshio, Abe, Masahiro
• Format: Journal Article
• Language: English
• Published: Japan The Japan Endocrine Society 25.04.2016
• Subjects: Adult; Aged; Aged, 80 and over; Ankle Brachial Index; Atherosclerosis; baPWV; Cardiovascular Diseases - etiology; Cardiovascular Diseases - physiopathology; Carotid Artery Diseases - blood; Carotid Artery Diseases - physiopathology; Carotid Intima-Media Thickness; Collagen Type I - blood; Disease Progression; Female; Humans; ICTP; Male; Max IMT; Middle Aged; Peptides - blood; Pulse Wave Analysis; Risk Factors
• ISSN: 0918-8959; 1348-4540
• DOI: 10.1507/endocrj.EJ15-0589

Carboxy-terminal telopeptide of type I collagen (ICTP) is generated through matrix metalloproteinase (MMP)-dependent type I collagen digestion, and has been widely utilized as a biomarker for bone turnover. The fact that atherosclerotic lesions are rich in both type I collagen and MMP-producing macrophages led to the hypothesis that serum ICTP concentrations may serve as a non-invasive clinical biomarker for atherosclerosis. Therefore, the association of serum ICTP concentrations with the maximum intima-media thickness (IMT) of carotid arteries, a surrogate index of systemic atherosclerosis, or brachial-ankle pulse wave velocity (baPWV) in patients with atherosclerotic risk factors was evaluated. A total of 52 male and 65 female (mean age: 62.8 yrs) patients without renal failure, malignancies or bone diseases known to affect serum ICTP concentrations were recruited. Patients with max IMTs ≥1.1 mm showed significantly higher serum ICTP concentrations compared with patients with max IMTs <1.1 mm (3.33 ± 0.97 vs 2.82 ± 0.65 ng/mL, p<0.05). Serum ICTP concentration was also positively correlated with max IMT (p<0.001) or baPWV values (p<0.05). Multivariate analyses also revealed that serum ICTP concentrations were correlated with max IMT (p<0.001; 95% CI 0.200 to 0.454). These results suggest that serum ICTP concentrations can be used as a non-invasive biomarker for systemic atherosclerosis.