Huge tumoral calcinosis mimicking a sarcoma

• Published in: Indian journal of pathology & microbiology Vol. 62; no. 2; pp. 337 - 338
• Main Authors: Shenoy, Asha, Sathe, Pragati, Agnihotri, Mona
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.04.2019; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Amorphous materials; Calcification; Calcification (ectopic); Calcinosis; Care and treatment; Chemotherapy; Diagnosis; Diagnostic imaging; Excision (Surgery); Fibrosis; Histopathology; Hypotheses; Infiltration; Magnetic resonance imaging; Metastases; Mimicry; Muscles; Necrosis; Neoplasia; Neoplasms; Numbness; Pathogenesis; Phosphorus; Sarcoma; Sciatic nerve; Skin; Soft tissue sarcoma; Soft tissues; Thigh; Tissues; Tumors
• ISSN: 0377-4929; 0974-5130
• DOI: 10.4103/IJPM.IJPM_268_18

The magnetic resonance imaging showed a large soft tissue mass in the left gluteal region extending into the proximal and posterior compartment of thigh with extensive involvement of sciatic nerve and erosion of left pubic ramus [Figure 1]a. Based on the radiologic impression of a soft tissue sarcoma, patient was administered chemotherapeutic drugs. There was no rim of normal tissue at the periphery [Figure 1]b and [Figure 1]c. The histopathology showed extensive dystrophic calcification surrounded by foreign body giant cell reaction, fibroblastic proliferation, necrosis, hemosiderin pigment deposition, and mononuclear cell inflammation [Figure 1]d,[Figure 1]e,[Figure 1]f. There was ulceration of skin and infiltration of muscle. [3] The characteristic histologic feature of amorphous calcified material surrounded by foreign body giant cell reaction and fibrosis distinguishes it from other causes of soft tissue calcification and neoplasms.