The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?

Chloride intracellular channel proteins (CLICs) are distinct from most ion channels in that they have both soluble and integral membrane forms. CLICs are highly conserved in chordates, with six vertebrate paralogues. CLIC-like proteins are found in other metazoans. CLICs form channels in artificial...

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Published inFEBS letters Vol. 584; no. 10; pp. 2093 - 2101
Main Authors Littler, Dene R., Harrop, Stephen J., Goodchild, Sophia C., Phang, Juanita M., Mynott, Andrew V., Jiang, Lele, Valenzuela, Stella M., Mazzanti, Michele, Brown, Louise J., Breit, Samuel N., Curmi, Paul M.G.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 17.05.2010
Subjects
Animals
Cell Membrane - metabolism
Chloride Channels - chemistry
Chloride Channels - classification
Chloride Channels - genetics
Chloride Channels - metabolism
chloride intracellular channel
Chloride intracellular channel protein
Chordata
CLIC
CLIC1
Cytoskeleton - metabolism
dehydroascorbate reductase
DHAR
endoplasmic reticulum
Enzymes - chemistry
Enzymes - classification
Enzymes - genetics
Enzymes - metabolism
ERM
ezrin–moesin–radixin
glutaredoxin
glutathione
glutathione S-transferase
Grx
GSH
GST
GST omega
GSTO
Humans
Hydrogen-Ion Concentration
Membrane insertion
Metazoa
Oxidation-Reduction
Redox
transmembrane
Tubulogenesis
ERM
GSTO
Redox
GST
DHAR
Chloride intracellular channel protein
Grx
ER
Tubulogenesis
TM
CLIC
GSH
CLIC1
Membrane insertion
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Summary:Chloride intracellular channel proteins (CLICs) are distinct from most ion channels in that they have both soluble and integral membrane forms. CLICs are highly conserved in chordates, with six vertebrate paralogues. CLIC-like proteins are found in other metazoans. CLICs form channels in artificial bilayers in a process favoured by oxidising conditions and low pH. They are structurally plastic, with CLIC1 adopting two distinct soluble conformations. Phylogenetic and structural data indicate that CLICs are likely to have enzymatic function. The physiological role of CLICs appears to be maintenance of intracellular membranes, which is associated with tubulogenesis but may involve other substructures.
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ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2010.01.027