Conscious and Subliminal Conflicts in Normal Subjects and Patients with Schizophrenia: The Role of the Anterior Cingulate

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 100; no. 23; pp. 13722 - 13727
• Main Authors: Dehaene, Stanislas, Artiges, Eric, Naccache, Lionel, Martelli, Catherine, Viard, Armelle, Schürhoff, Franck, Recasens, Christophe, Marie Laure Paillère Martinot, Leboyer, Marion, Martinot, Jean-Luc
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 11.11.2003; National Acad Sciences
• Subjects: Adolescent; Adult; Anatomy; Attention; Behavior; Behavioral neuroscience; Biological Sciences; Brain; Brain - pathology; Brain Mapping; Case-Control Studies; Conflict (Psychology); Consonants; Experimentation; Frontal Lobe - pathology; Gyrus Cinguli - pathology; Gyrus Cinguli - physiology; Hippocampus - metabolism; Humans; Magnetic Resonance Imaging; Male; Mental disorders; Neuroimaging; Prefrontal cortex; Prime numbers; Psychology; Psychomotor Performance; Schizophrenia; Schizophrenia - physiopathology; Scientific imaging; Subliminal perception; Temporal Lobe - metabolism
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2235214100

The human anterior cingulate cortex (ACC), which is active during conflict-monitoring tasks, is thought to participate with prefrontal cortices in a distributed network for conscious self-regulation. This hypothesis predicts that conflict-related ACC activation should occur only when the conflicting stimuli are consciously perceived. To dissociate conflict from consciousness, we measured the behavioral and brain imaging correlates of a motor conflict induced by task-irrelevant subliminal or conscious primes. The same task was studied in normal subjects and in patients with schizophrenia in whom the ACC and prefrontal cortex are thought to be dysfunctional. Conscious, but not subliminal, conflict affected anterior cingulate activity in normal subjects. Furthermore, patients with schizophrenia, who exhibited a hypoactivation of the ACC and other frontal, temporal, hippocampal, and striatal sites, showed impaired conscious priming but normal subliminal priming. Those findings suggest that subliminal conflicts are resolved without ACC contribution and that the ACC participates in a distributed conscious control network that is altered in schizophrenia.