Increased apelin receptor gene expression in the subfornical organ of spontaneously hypertensive rats

• Published in: PloS one Vol. 15; no. 4; p. e0231844
• Main Authors: Griffiths, Philip R, Lolait, Stephen J, Bijabhai, Aarifah, O'Carroll-Lolait, Aoife, Paton, Julian F R, O'Carroll, Anne-Marie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.04.2020; Public Library of Science (PLoS)
• Subjects: Animals; Apelin - metabolism; Apelin Receptors - metabolism; Area postrema; Autonomic nervous system; Biology and Life Sciences; Blood pressure; Blood-brain barrier; Brain; Experiments; Gene expression; Health sciences; Histochemistry; Histology; Homeostasis; Hybridization; Hypertension; Hypertension - metabolism; Hypertension - pathology; In Situ Hybridization, Fluorescence; Level (quantity); Male; Medical schools; Medicine and Health Sciences; Microinjection; Neuronal-glial interactions; Neurons - metabolism; Neurons - pathology; Organs; Phenotypes; Physiology; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors; Research and Analysis Methods; Rodents; Sense organs; Signal transduction; Subfornical organ; Subfornical Organ - metabolism; Subfornical Organ - pathology; Up-Regulation; United Kingdom > UK

The vascular organ of the lamina terminalis, subfornical organ (SFO), and area postrema comprise the sensory circumventricular organs (CVO) which are central structures that lie outside the blood brain barrier and are thought to provide an interface between peripherally circulating signals and the b...