Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity

• Published in: PloS one Vol. 13; no. 11; p. e0206769
• Main Authors: Yen, Ting-Yu, Shih, Wei-Liang, Huang, Yi-Chuan, Lee, Jian-Te, Huang, Li-Min, Chang, Luan-Yin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.11.2018; Public Library of Science (PLoS)
• Subjects: Annexin A2 - genetics; Annexin II; Biology and Life Sciences; Case-Control Studies; Central nervous system; Chemokines; Child, Preschool; Complications; Cytokines; Disease; Enterovirus A, Human - pathogenicity; Enterovirus Infections - genetics; Enterovirus Infections - virology; Enteroviruses; Epidemics; Evolution & development; Families & family life; Female; Genetic Predisposition to Disease; Glycoproteins; Health care; Hospitals; Humans; Infant; Infections; Ligands; Lysosomal Membrane Proteins - genetics; Male; Medicine and Health Sciences; Membrane Glycoproteins - genetics; P-selectin; P-selectin glycoprotein ligand 1; Pathogenesis; Pediatrics; Polymorphism, Single Nucleotide; Preventive medicine; Proteins; Receptors; Receptors, Scavenger - genetics; Receptors, Virus - genetics; Scavenger receptors; Severity of Illness Index; Taiwan; Tumor necrosis factor-TNF; Viral infections; Taiwan; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0206769

To evaluate the association of enterovirus 71 (EV71) susceptibility and clinical severity with polymorphisms in EV71 receptors, including human scavenger receptor class B member 2 (SCARB2), P-selectin glycoprotein ligand-1 (PSGL-1), and annexin II (ANXA2). We enrolled laboratory-confirmed EV71 cases...