Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity

• Published in: PloS one Vol. 13; no. 11; p. e0206769
• Main Authors: Yen, Ting-Yu, Shih, Wei-Liang, Huang, Yi-Chuan, Lee, Jian-Te, Huang, Li-Min, Chang, Luan-Yin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.11.2018; Public Library of Science (PLoS)
• Subjects: Annexin A2 - genetics; Annexin II; Biology and Life Sciences; Case-Control Studies; Central nervous system; Chemokines; Child, Preschool; Complications; Cytokines; Disease; Enterovirus A, Human - pathogenicity; Enterovirus Infections - genetics; Enterovirus Infections - virology; Enteroviruses; Epidemics; Evolution & development; Families & family life; Female; Genetic Predisposition to Disease; Glycoproteins; Health care; Hospitals; Humans; Infant; Infections; Ligands; Lysosomal Membrane Proteins - genetics; Male; Medicine and Health Sciences; Membrane Glycoproteins - genetics; P-selectin; P-selectin glycoprotein ligand 1; Pathogenesis; Pediatrics; Polymorphism, Single Nucleotide; Preventive medicine; Proteins; Receptors; Receptors, Scavenger - genetics; Receptors, Virus - genetics; Scavenger receptors; Severity of Illness Index; Taiwan; Tumor necrosis factor-TNF; Viral infections; Taiwan; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0206769

To evaluate the association of enterovirus 71 (EV71) susceptibility and clinical severity with polymorphisms in EV71 receptors, including human scavenger receptor class B member 2 (SCARB2), P-selectin glycoprotein ligand-1 (PSGL-1), and annexin II (ANXA2). We enrolled laboratory-confirmed EV71 cases and healthy age- and gender-matched controls in Taiwan from 2000 to 2012. We detected genetic polymorphisms in SCARB2, PSGL-1, and ANXA2 and correlated the results with EV71 susceptibility and severity. We collected 599 EV71 cases and 98 controls. Among EV71 patients, the male to female ratio was 1.61, and the mean age was 2.99±2.47 years. For clinical severity, 117 (19.6%) had severe central nervous system involvement with or without cardiopulmonary failure. For outcomes, 46 (7.7%) had sequelae, and 14 (2.3%) died. SCARB2 polymorphisms (rs6824953 and rs11097262) were associated with susceptibility to EV71 infection (OR 1.60, 95% CI 1.07-2.39; and OR 1.64, 95% CI 1.09-2.47, respectively). PSGL-1 polymorphisms (rs7137098 and rs8179137) were significantly associated with severe EV71 infection (OR 1.46, 95% CI 1.1-1.96; and OR 1.47, 95% CI 1.07-2.03, respectively). SCARB2 polymorphisms (rs6824953 and rs11097262) might be associated with EV71 susceptibility. PSGL-1 polymorphisms (rs7137098 and rs8179137) were associated with severe EV71 infection.