How alkalinization drives fungal pathogenicity

While the details on the mode of action of F-RALF remain to be elucidated, it was recently shown that endogenous RALF-FERONIA signaling leads to inactivation of the plasma membrane H+-ATPase AHA2 and inhibition of plant cell elongation [27]. [...]FERONIA integrates signals from other plant hormones,...

Full description

Saved in:
Bibliographic Details
Published inPLoS pathogens Vol. 13; no. 11; p. e1006621
Main Authors Fernandes, Tânia R, Segorbe, David, Prusky, Dov, Di Pietro, Antonio
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.11.2017
Public Library of Science (PLoS)
Subjects
Abscisic acid
Acidification
Amino acids
Ammonia
Biology and Life Sciences
Candida albicans
Deactivation
Elongation
Fungi
Gene expression
Homeostasis
Hormones
Infections
Kinases
Magnaporthe oryzae
Medicine and Health Sciences
Membranes
Pathogenicity
Pathogens
Pearls
Physical Sciences
Saccharomyces cerevisiae
Signal transduction
Signaling
Virulence
Online AccessGet full text

Cover

More Information
Summary:While the details on the mode of action of F-RALF remain to be elucidated, it was recently shown that endogenous RALF-FERONIA signaling leads to inactivation of the plasma membrane H+-ATPase AHA2 and inhibition of plant cell elongation [27]. [...]FERONIA integrates signals from other plant hormones, such as auxin and abscisic acid [28]. Interestingly, the Pma2 clade is present in many phytopathogenic ascomycetes and absent in nonpathogenic species. [...]the acquisition of a second plasma membrane H+-ATPase, in addition to Pma1, with a specific role in virulence, appears to represent a common strategy of ascomycete pathogens. [...]research is also needed to elucidate the pH-sensing processes that link extracellular alkalinization to known pathogenicity signaling modules, such as the Pal/Rim pathway or the IG MAPK cascade. Besides the plasma membrane protein PalH, whose precise mode of pH sensing remains to be defined, additional pH sensors must exist. [...]the recent finding that different antifungals induce a dramatic decrease of pHi in Candida [46, 47], combined with the broadly conserved role of alkalinization in virulence, makes alkalinization an attractive target for the control of fungal pathogens.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Current address: Charles University, BIOCEV, Vestec, Czechia
The authors have declared that no competing interests exist.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1006621