Hericenols A–D and a chromanone from submerged cultures of a Stereum species

• Published in: Phytochemistry (Oxford) Vol. 60; no. 4; pp. 431 - 435
• Main Authors: Omolo, Josiah Ouma, Anke, Heidrun, Sterner, Olov
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.06.2002; Elsevier
• Subjects: 2-dimethylchroman-4-one; 6-hydroxymethyl-2; 6-Hydroxymethyl-2,2-dimethylchroman-4-one; Animals; Basidiomycete; Basidiomycota - chemistry; Basidiomycota - drug effects; Basidiomycota - isolation & purification; Biochemistry & Molecular Biology; Biological and medical sciences; Chemical constitution; Chemical Sciences; Chromatography - methods; Chromones - chemistry; Chromones - isolation & purification; Chromones - pharmacology; Colon - cytology; Colon - drug effects; COS Cells; Erinapyrone C; Fundamental and applied biological sciences. Psychology; General pharmacology; Hericenols A–D; Kemi; Kenya; Leukemia L1210; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy - methods; Medical sciences; Microbial Sensitivity Tests; Natural Sciences; Naturvetenskap; Organic Chemistry; Organisk kemi; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phenols - chemistry; Phenols - metabolism; Phenols - pharmacology; Plant physiology and development; Plant Sciences; Science & Technology; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Stereum species; Kenya; Basidiomycete; 6-Hydroxymethyl-2,2-dimethylchroman-4-one; Hericenols A–D; Erinapyrone C; Stereum species; basidiomycete; 6-hydroxymethyl-2,2-dimethylchroman-4-one; NATURAL-PRODUCTS; MUSHROOM HERICIUM-ERINACEUM; hericenols A-D; erinapyrone C; Human; Bioassay; Molecular structure; Pharmacognosy; Monkey; Basidiomycetes; Cytotoxicity; Kidney; Biological activity; Antimicrobial agent; Medicinal plant; Fungi; Vertebrata; Cell line; Mammalia; Stereum; Plant origin; Primates; Phenols; Isolation; Colon; Thallophyta
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(02)00070-5

Extracts of submerged cultures of a Stereum species afforded four new pentasubstituted phenolic compounds, named hericenols A, B, C, and D ( 1– 4), 6-hydroxymethyl-2,2-dimethylchroman-4-one ( 5) and the known erinapyrone C. Hericenol A ( 1) showed weak antimicrobial activity while hericenol C ( 3) was weakly cytotoxic. The structures of the metabolites were determined by spectroscopic techniques. Four substituted phenols, e.g. hericenol A ( 1), were isolated from fermentations of a Stereum species.