Exosomal Noncoding RNAs and Tumor Drug Resistance

Tumor drug resistance is a major challenge in the treatment of cancer. Noncoding RNAs (ncRNA) play a role in the progression of drug resistance. Recent studies have indicated that exosomes, with their and compatibility, are the best natural carrier of ncRNA, and their transport of ncRNA into cells c...

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Published inCancer research (Chicago, Ill.) Vol. 80; no. 20; pp. 4307 - 4313
Main Authors Guo, Chengyao, Liu, Jinbo, Zhou, Quanbo, Song, Junmin, Zhang, Zhiyong, Li, Zhen, Wang, Guixian, Yuan, Weitang, Sun, Zhenqiang
Format Journal Article
LanguageEnglish
Published United States 15.10.2020
Subjects
Animals
Biomarkers, Tumor - genetics
Drug Resistance, Neoplasm - genetics
Exosomes - genetics
Gene Expression Regulation, Neoplastic
Humans
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - pathology
RNA, Untranslated - physiology
Signal Transduction - drug effects
Signal Transduction - genetics
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Summary:Tumor drug resistance is a major challenge in the treatment of cancer. Noncoding RNAs (ncRNA) play a role in the progression of drug resistance. Recent studies have indicated that exosomes, with their and compatibility, are the best natural carrier of ncRNA, and their transport of ncRNA into cells could regulate drug resistance. Exosomal ncRNA impact drug resistance through participation in drug efflux, regulation of signaling pathways, and modification of the tumor microenvironment. In this review, we evaluate the mechanism of exosomal ncRNA related to tumor drug resistance, their role in different tumors, and potential clinical applications.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.can-20-0032