Serum Bicarbonate in Acute Heart Failure: Relationship to Treatment Strategies and Clinical Outcomes

• Published in: Journal of cardiac failure Vol. 22; no. 9; pp. 738 - 742
• Main Authors: Cooper, Lauren B., MD, Mentz, Robert J., MD, Gallup, Dianne, MS, Lala, Anuradha, MD, DeVore, Adam D., MD, Vader, Justin M., MD, MS, AbouEzzeddine, Omar F., MD, Bart, Bradley A., MD, Anstrom, Kevin J., PhD, Hernandez, Adrian F., MD, MHS, Felker, G. Michael, MD, MHS
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2016
• Subjects: Acute Disease; Aged; Bicarbonates - blood; Biomarkers - blood; Cardiovascular; Chi-Square Distribution; Disease Progression; Diuretics; Diuretics - therapeutic use; Edema; Female; Heart failure; Heart Failure - blood; Heart Failure - drug therapy; Heart Failure - mortality; Humans; Linear Models; Male; Middle Aged; Predictive Value of Tests; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Severity of Illness Index; Statistics, Nonparametric; Survival Analysis; Treatment Outcome; Heart failure; Diuretics; Edema
• ISSN: 1071-9164; 1532-8414
• DOI: 10.1016/j.cardfail.2016.01.007

Highlights • Elevated serum bicarbonate is a common observation in acute heart failure (AHF) patients. • In AHF, bicarbonate increased with diuretics but decreased with ultrafiltration. • Bicarbonate change was not associated with clinical signs of decongestion. • Adequate decongestion is a key goal in the treatment of patients with AHF. • Modest increases in bicarbonate should not prompt decrease or cessation of diuresis.