Polyurethane elastomer biostability

Polyurethanes have unique mechanical and biologic properties that make them ideal for many implantable devices. They are subject to some in vivo degradation mechanisms, however. Polyester polyurethanes are subject to hydrolytic degradation and are no longer used in long-term implanted devices. Polye...

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Bibliographic Details
Published inJournal of biomaterials applications Vol. 9; no. 4; p. 321
Main Authors Stokes, K, McVenes, R, Anderson, J M
Format Journal Article
LanguageEnglish
Published England 01.04.1995
Subjects
Animals
Biocompatible Materials
Body Fluids - chemistry
Calcinosis - physiopathology
Environmental Exposure
Foreign-Body Reaction - immunology
Materials Testing
Metals - chemistry
Molecular Conformation
Oxidation-Reduction
Physical Phenomena
Physics
Polyurethanes - chemistry
Prostheses and Implants
Stress, Mechanical
Surface Properties
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Summary:Polyurethanes have unique mechanical and biologic properties that make them ideal for many implantable devices. They are subject to some in vivo degradation mechanisms, however. Polyester polyurethanes are subject to hydrolytic degradation and are no longer used in long-term implanted devices. Polyether polyurethanes, while hydrolytically stable, are subject to oxidative degradation in several forms, including environmental stress cracking and metal ion oxidation. Mineralization is also known to occur. A new polycarbonate polyurethane has superior biostability in early in vivo qualification tests compared to the polyether polyurethanes, including no evidence of hydrolysis, ESC or MIO.
ISSN:0885-3282
DOI:10.1177/088532829500900402