Exosomal communication goes viral

Exosomes are small vesicles secreted from cells that participate in intercellular communication events. Accumulating evidence demonstrates that host exosome pathways are hijacked by viruses and that virally modified exosomes contribute to virus spread and immune evasion. In the case of tumor viruses...

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Bibliographic Details
Published inJournal of virology Vol. 89; no. 10; pp. 5200 - 5203
Main Author Meckes, Jr, David G
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.05.2015
Subjects
Cell Communication - physiology
Epstein-Barr virus
Epstein-Barr Virus Infections - immunology
Epstein-Barr Virus Infections - physiopathology
Epstein-Barr Virus Infections - virology
Exosomes - physiology
Exosomes - virology
Gems
Herpesvirus 4, Human - immunology
Herpesvirus 4, Human - pathogenicity
Herpesvirus 4, Human - physiology
Host-Pathogen Interactions
Humans
Immune Evasion
Models, Biological
Viral Matrix Proteins - physiology
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Summary:Exosomes are small vesicles secreted from cells that participate in intercellular communication events. Accumulating evidence demonstrates that host exosome pathways are hijacked by viruses and that virally modified exosomes contribute to virus spread and immune evasion. In the case of tumor viruses, recent findings suggest that alterations in normal exosome biology may promote the development and progression of cancer. These studies will be discussed in the context of our current knowledge of Epstein-Barr virus (EBV)-modified exosomes.
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Citation Meckes DG, Jr. 2015. Exosomal communication goes viral. J Virol 89:5200–5203. doi:10.1128/JVI.02470-14.
ISSN:0022-538X
1098-5514
DOI:10.1128/jvi.02470-14