Novel application of a radial water tread maze can distinguish cognitive deficits in mice with traumatic brain injury

Highlights • A species-appropriate cognitive test is evaluated in a mouse model of TBI. • This Radial Water Tread maze was designed for mice and requires no swimming. • Latency to escape the maze was significantly higher in TBI mice compared to Shams. • TBI cognitive deficits were significant even a...

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Bibliographic Details
Published inBrain research Vol. 1657; pp. 140 - 147
Main Authors Cline, Marcella M, Yumul, Josh, Hysa, Lisa, Murra, Dalia, Garwin, Gregory G, Cook, David G, Ladiges, Warren, Minoshima, Satoshi, Cross, Donna J
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.02.2017
Subjects
Animals
Behavior, Animal
Behavioral testing
Brain Injuries, Traumatic - complications
Brain Injuries, Traumatic - diagnosis
Brain Injuries, Traumatic - psychology
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Cognitive testing
Controlled-cortical impact
Disease Models, Animal
Gait
Male
Maze Learning
Mice, Inbred C57BL
Motor Activity
Neurology
Neuropsychological Tests
Traumatic brain injury
Water maze
Radial Water Tread
MWM
Traumatic brain injury
Controlled-cortical impact
behavioral testing
water maze
CCI
TBI
Morris Water Maze
RWT
cognitive testing
Behavioral testing
Cognitive testing
Water maze
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Summary:Highlights • A species-appropriate cognitive test is evaluated in a mouse model of TBI. • This Radial Water Tread maze was designed for mice and requires no swimming. • Latency to escape the maze was significantly higher in TBI mice compared to Shams. • TBI cognitive deficits were significant even after most motor issues had resolved.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2016.11.027