Associations of lipid profiles with insulin resistance and β cell function in adults with normal glucose tolerance and different categories of impaired glucose regulation

• Published in: PloS one Vol. 12; no. 2; p. e0172221
• Main Authors: Zheng, Shuang, Xu, Hua, Zhou, Huan, Ren, Xingxing, Han, Tingting, Chen, Yawen, Qiu, Huiying, Wu, Peihong, Zheng, Jun, Wang, Lihua, Liu, Wei, Hu, Yaomin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.02.2017; Public Library of Science (PLoS)
• Subjects: Adult; Adults; Biology and Life Sciences; Blood Glucose - analysis; Categories; Cholesterol; Cholesterol - blood; Cholesterol, HDL - blood; Correlation analysis; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Dyslipidemia; Dyslipidemias - diagnosis; Dyslipidemias - pathology; Endocrinology; Fasting; Female; Glucose; Glucose - metabolism; Glucose tolerance; Glucose Tolerance Test; High density lipoprotein; Hospitals; Humans; Insulin; Insulin Resistance; Insulin-Secreting Cells - metabolism; Lipids; Lipids - blood; Lipoproteins (high density); Low level; Male; Medicine; Medicine and Health Sciences; Metabolic disorders; Middle Aged; Regression Analysis; Rodents; Sensitivity analysis; Triglycerides - blood
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0172221

To investigate the associations of dyslipidemia with insulin resistance and β cell function in individuals with normal glucose tolerance (NGT) and different categories of impaired glucose regulation (IGR). 544 subjects (365 with dyslipidemia and/or IGR and 179 with normal lipid and glucose tolerance) were enrolled in the study. All subjects underwent oral glucose tolerance test (OGTT). HOMA-IR was used to evaluate insulin sensitivity. Disposition index (DI) was used to evaluate β cell function. Multiple linear regression analysis was performed to assess correlations among lipid profiles, insulin resistance and β cell function. Among subjects with NGT, those with dyslipidemia had higher level of HOMA-IR but lower level of DI. While among subjects with different categories of IGR, those with dyslipidemia and CGI had significantly decreased DI. No obvious differences of insulin resistance or β cell function were found in IFG or IGT subjects with or without dyslipidemia. TG and HDL-C were correlated with HOMA-IR (β = 0.79, p <0.001; β = -0.38, p = 0.027, respectively, compared with subjects in the low level groups). Moreover, TG and TC were negatively correlated with DI (β = -2.17, p = 0.013; β = -2.01, p = 0.034 respectively, compared with subjects in the low level groups) after adjusting for confounding parameters. Dyslipidemia induces insulin resistance and impaired β cell response to insulin resistance in individuals with NGT. Furthermore, dyslipidemia diminishes β cell function in subjects with CGI. TG and HDL-C were correlated with insulin resistance, and TG, TC were negatively correlated with β cell response to insulin resistance in non-diabetic individuals.