Effects of Cholinergic Agonists and Antagonists under Conditions of Spleen Denervation in Rats with Endotoxic Shock

• Published in: Bulletin of experimental biology and medicine Vol. 149; no. 5; pp. 598 - 600
• Main Authors: Sapronov, N. S, Nezhinskaya, G. I, Vladykin, A. L
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.10.2010; Springer US; Springer; Springer Nature B.V
• Subjects: Animals; Atropine - pharmacology; B cells; Biomedical and Life Sciences; Biomedicine; Cell Biology; Choline; cholinergic agonists; Cholinergic Agonists - pharmacology; cholinergic antagonists; Denervation; endotoxic shock; Galantamine - pharmacology; Galanthamine; Glycerylphosphorylcholine; Heart Rate - drug effects; Internal Medicine; Ipratropium - pharmacology; Laboratory Medicine; Lipopolysaccharides; Male; Muscarinic Antagonists - pharmacology; Nicotinic Agonists - pharmacology; Pathology; Rats; Rats, Wistar; Salmonella typhi; Salmonella typhi - immunology; Septic shock; serotonin; Serotonin - metabolism; Shock, Septic - immunology; Spleen - innervation; spleen denervation; endotoxic shock; cholinergic antagonists; serotonin; spleen denervation; B cells; cholinergic agonists
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-010-1002-4

Model experiments on rats with endotoxic shock induced by intraperitoneal injection of LPS Salmonella Typhi strain ty-4441 (20 mg/kg) showed that crossing of the vagus nerve innervating the spleen increased HR, stimulated production of antibodies, and moderated serotonergic activity of splenocytes. Pharmacological correction of the shock with muscarinic receptor antagonist atropine and its combinations with anticholinesterase agent galantamine or muscarinic and nicotinic cholinoreceptor agonist choline alfoscerate 30 min before shock modeling moderated HR and normalized B cell functions and serotonin level in the spleen.