Changes in CoA Pools in Hepatic Peroxisomes of the Rat, under Various Conditions
Changes in peroxisomal CoA pools in the liver of fasted, diabetic, high-fat diet-fed and clofibrate-treated rats were studied. Total-CoA increased slightly in the fasted group and markedly in the diabetic, high-fat and clofibrate-treated groups. Fractionation studies showed that changes in free CoA...
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Published in | Journal of biochemistry (Tokyo) Vol. 99; no. 5; pp. 1345 - 1352 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Oxford University Press
01.05.1986
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Subjects | |
Online Access | Get full text |
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Summary: | Changes in peroxisomal CoA pools in the liver of fasted, diabetic, high-fat diet-fed and clofibrate-treated rats were studied. Total-CoA increased slightly in the fasted group and markedly in the diabetic, high-fat and clofibrate-treated groups. Fractionation studies showed that changes in free CoA levels were much greater in peroxisomes than in mitochondria. The concentrations of CoAs were calculated from the contents of CoAs in organelles and the changes in volume of organelles under these conditions; the concentration of total CoA in peroxisomes was higher than that in cytosol, but lower than that in mitochondria. These changes were accompanied by an increase in the activity of peroxisomal β-oxidation. The results obtained from these experiments indicate that the peroxisomal β-oxidation system is controlled not only at the enzyme level but also at the substrate or co-factor level. |
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Bibliography: | ark:/67375/HXZ-D2N5NKVM-B ArticleID:99.5.1345 istex:9E0707952FDA58CDDBDC5BF02F7AA4C192A02A01 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0021-924X 1756-2651 |
DOI: | 10.1093/oxfordjournals.jbchem.a135602 |