Spatial patterns and cell surface clusters in perineuronal nets

• Published in: Brain research Vol. 1648; no. Pt A; pp. 214 - 223
• Main Authors: Arnst, Nikita, Kuznetsova, Svetlana, Lipachev, Nikita, Shaikhutdinov, Nurislam, Melnikova, Anastasiya, Mavlikeev, Mikhail, Uvarov, Pavel, Baltina, Tatyana V, Rauvala, Heikki, Osin, Yuriy N, Kiyasov, Andrey P, Paveliev, Mikhail
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2016
• Subjects: Animals; Cell surface compartments; Chondroitin Sulfate Proteoglycans - metabolism; Chondroitinsulfate proteoglycans; Extracellular matrix; Extracellular Matrix - metabolism; Mice; Nerve Net - cytology; Nerve Net - metabolism; Neurology; Neurons - cytology; Neurons - metabolism; Perineuronal nets; Plant Lectins - metabolism; Rats; Receptors, N-Acetylglucosamine - metabolism; Somatosensory cortex; Somatosensory Cortex - cytology; Somatosensory Cortex - metabolism; Synaptic plasticity; Wisteria floribunda; chondroitinsulfate proteoglycans; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; postsynaptic density protein 95; glial cell-derived neurotrophic factor; N-acetyl-galactosamine; NT-3; CNS; Sema3A; PNN; 2D; WFA; Semaphorin-3A; brain-derived neurotrophic factor; 3-dimensional; receptor-type tyrosine-protein phosphatase S; perineuronal nets; FGF; BDNF; chondroitin sulfate; root mean square deviation; VEGF; RMSD; PTPsigma; ECM; central nervous system; GalNAc; CS; 3D; fibroblast growth factors; AMPA receptor; Wisteria floribunda agglutinin; PSD95; two-dimensional; GDNF; vascular endothelial growth factor; chondroitin sulfate proteoglycans; cell surface compartments; CSPG; somatosensory cortex; synaptic plasticity; neurotrophin-3; extracellular matrix; Somatosensory cortex; Synaptic plasticity; Extracellular matrix; Chondroitinsulfate proteoglycans; Cell surface compartments; Perineuronal nets

Abstract Perineuronal nets (PNN) ensheath GABAergic and glutamatergic synapses on neuronal cell surface in the central nervous system (CNS), have neuroprotective effect in animal models of Alzheimer disease and regulate synaptic plasticity during development and regeneration. Crucial insights were o...