Stressing the role of FoxO proteins in lifespan and disease

• Published in: Nature reviews. Molecular cell biology Vol. 8; no. 6; pp. 440 - 450
• Main Authors: Burgering, Boudewijn M.T, van der Horst, Armando
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.06.2007
• Subjects: Active oxygen; Aging - physiology; Animals; Apoptosis; Diabetes; Disease; DNA binding proteins; Drosophila; Energy consumption; Enzymes; Forkhead Transcription Factors - classification; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Genetic aspects; Glucose; Glucose - metabolism; Growth factors; Humans; Insulin; Kinases; Life Expectancy; Life span; Models, Biological; Oxidative stress; Phosphorylation; Physiological aspects; Protein Isoforms - classification; Protein Isoforms - genetics; Protein Isoforms - metabolism; Protein Processing, Post-Translational; Proteins; Transcription factors; Tumor Suppressor Protein p53 - metabolism; Netherlands
• ISSN: 1471-0072; 1471-0080
• DOI: 10.1038/nrm2190

Members of the class O of forkhead box transcription factors (FoxO) have important roles in metabolism, cellular proliferation, stress tolerance and probably lifespan. The activity of FoxOs is tightly regulated by post-translational modifications, including phosphorylation, acetylation and ubiquitylation. Several of the enzymes that regulate the turnover of these post-translational modifications are shared between FoxO and p53. These regulatory enzymes affect FoxO and p53 function in an opposite manner. This shared yet opposing regulatory network between FoxOs and p53 may underlie a 'trade-off' between disease and lifespan.