Analyses of Serum Concentrations of Apolipoproteins in the Demented Elderly

• Published in: Internal Medicine Vol. 39; no. 3; pp. 220 - 222
• Main Author: WADA, Hiroo
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 2000; Japanese Society of Internal Medicine
• Subjects: Aged; Alzheimer Disease - blood; Alzheimer Disease - diagnosis; Apo CII; Apo E; Apolipoproteins - blood; Biological and medical sciences; Biomarkers - blood; correlation coefficient; Dementia, Vascular - blood; Dementia, Vascular - diagnosis; Diagnosis, Differential; Electroencephalography; Female; Humans; Immunoenzyme Techniques; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Male; Medical sciences; Nervous system; Outpatients; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; senile dementia; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Human; Nervous system diseases; Biochemical analysis; Apolipoprotein; Concentration; Cerebral disorder; Senile dementia; Result; Central nervous system disease; Risk factor; Degenerative disease; Molecular biology; Elderly; Comparative study
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.39.220

Objective The aim was to analyze serum concentrations of apolipoproteins in the demented elderly to elucidate some biological markers related to dementia. Patients and Methods Serum concentrations of apolipoproteins (AI, AH, B, CII, CIII, E) of patients with Alzheimer type dementia (AD), vascular dementia (VD) and controls (C) without dementia were compared among the three groups (AD, VD, C) and 15 correlation coefficients among the 6 measured items of apolipoproteins were analyzed. Results Serum levels of apo CII were significantly lower in AD group compared with VD or C groups. Serum levels of apo B, CIII and E were significantly lower in AD group compared with VD group, but not with C group. Analyses of correlations among the items of apolipoproteins revealed high significant correlations between apo E and/or apo CII and other items in AD group. Conclusion These results suggest that apolipoproteins such as apo CII, as well as apo E, might be involved in the pathogenesis of AD. (Internal Medicine 39: 220-222, 2000)