Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance

• Published in: BBA - Biomembranes Vol. 1461; no. 2; pp. 217 - 236
• Main Authors: Bauer, Bettina E, Wolfger, Hubert, Kuchler, Karl
• Format: Book Review Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 06.12.1999
• Subjects: ABC protein; Antifungal Agents - metabolism; Antifungal drug resistance; ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Cellular detoxification; DNA-Binding Proteins - genetics; Drug Resistance, Microbial - genetics; Fungal Proteins - genetics; Fungal Proteins - metabolism; Fungus; Gene Expression Regulation, Fungal; Gene regulation; Multidrug Resistance-Associated Proteins; Organelle; Pathogen; PDR network; Peptide Elongation Factors - genetics; Pheromone secretion; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins; Schizosaccharomyces - genetics; Schizosaccharomyces - metabolism; Stress response; Trans-Activators - genetics; Transcription Factors - genetics; PDR network; Fungus; ABC protein; Gene regulation; Organelle; Cellular detoxification; Antifungal drug resistance; Pathogen; Stress response; Pheromone secretion
• ISSN: 0005-2736; 0006-3002; 1879-2642
• DOI: 10.1016/S0005-2736(99)00160-1

Saccharomyces cerevisiae was the first eukaryotic organism whose complete genome sequence has been determined, uncovering the existence of numerous genes encoding proteins of the ATP-binding cassette (ABC) family. Fungal ABC proteins are implicated in a variety of cellular functions, ranging from clinical drug resistance development, pheromone secretion, mitochondrial function, peroxisome biogenesis, translation elongation, stress response to cellular detoxification. Moreover, some yeast ABC proteins are orthologues of human disease genes, which makes yeast an excellent model system to study the molecular mechanisms of ABC protein-mediated disease. This review provides a comprehensive discussion and update on the function and transcriptional regulation of all known ABC genes from yeasts, including those discovered in fungal pathogens.