High uptake of systematic HIV counseling and testing and TB symptom screening at a primary care clinic in South Africa

• Published in: PloS one Vol. 9; no. 9; p. e105428
• Main Authors: Van Rie, Annelies, Clouse, Kate, Hanrahan, Colleen, Selibas, Katerina, Sanne, Ian, Williams, Sharon, Kim, Peter, Bassett, Jean
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.09.2014; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Adults; Clients; Coinfection - diagnosis; Coinfection - epidemiology; Coinfection - therapy; Counseling - statistics & numerical data; Disease transmission; Female; Health facilities; HIV; HIV Infections - diagnosis; HIV Infections - epidemiology; HIV Infections - therapy; Human immunodeficiency virus; Humans; Male; Mass Screening; Medical diagnosis; Medicine and Health Sciences; Middle Aged; Morbidity; Prevalence; Primary Health Care; Screening; South Africa; Sputum; Sustainability; Sustainable yield; Systematic review; Tuberculosis; Tuberculosis, Pulmonary - diagnosis; Tuberculosis, Pulmonary - epidemiology; Tuberculosis, Pulmonary - therapy; Young Adult; North Carolina; South Africa; United States > US; Maryland; Africa
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0105428

Timely diagnosis and treatment of tuberculosis (TB) and HIV is important to reduce morbidity and mortality, and break the cycle of ongoing transmission. We performed an implementation research study to develop a model for systematic TB symptom screening and HIV counseling and testing (HCT) for all adult clients at a primary care clinic and prospectively evaluate the 6-month coverage and yield, and 18-month sustainability at a primary care clinic in Johannesburg, South Africa. During the first 6 months, 26,515 visits occurred among 12,078 adults. The proportion of adults aware of their HIV status was 43.7% at the start of the first visit, increased to 84.6% at the end of the first visit, and to 90% at end of any visit during the first 6 months. During these 6 months, 1042 clients were newly diagnosed with HIV. HIV prevalence was 22.9% among those newly tested, and 58.9% among all adult clinic clients. High coverage of systematic HCT was sustained across all 18 months. Coverage of systematic HIV-stratified TB symptom screening during first 6-months was also high (89.6%) but only 35.0% of those symptomatic were screened by sputum. During these 6-months, 90 clients had a positive Xpert MTB/RIF assay, corresponding to a TB prevalence of 0.4% among all 23,534 clients TB symptom-screened and 2.8% among the 3,284 clients with a positive TB symptom screen. The initial high coverage of TB symptom screening was not sustained, with coverage of TB symptom screening dropping after the first six months to 70% and assessment by sputum dropping to 15%. Routine, systematic HCT and HIV-stratified TB symptom screening is feasible at primary care level. Systematic HCT doubled the proportion of clients with known HIV status. While HCT was sustainable, coverage of systematic TB screening dropped significantly after the first 6 months of implementation.