Syscan3, a Kit for Detection of Anti-Candida Antibodies for Diagnosis of Invasive Candidiasis

Sera from 76 immunocompetent and 293 immunocompromised subjects were assayed for anti-Candida antibodies. The sensitivity, specificity, positive predictive value, and negative predictive value for invasive candidiasis were 74%, 75%, 62%, and 84% in the immunocompetent group and 15%, 60%, 1.7%, and 9...

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Published inJournal of Clinical Microbiology Vol. 43; no. 9; pp. 4834 - 4835
Main Authors Philip, Annie, Odabasi, Zekaver, Matiuzzi, Gloria, Paetznick, Victor L, Tan, Sze-Wee, Warmington, John, Rex, John H, Ostrosky-Zeichner, Luis
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.09.2005
Subjects
Antibodies, Fungal - blood
Antigens, Fungal - immunology
Biological and medical sciences
Candida - classification
Candida - immunology
Candidiasis - diagnosis
Candidiasis - microbiology
Enzyme-Linked Immunosorbent Assay - methods
Fundamental and applied biological sciences. Psychology
Fungemia - diagnosis
Fungemia - microbiology
Humans
Immunocompetence
Immunocompromised Host
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Mycology
Predictive Value of Tests
Reagent Kits, Diagnostic
Sensitivity and Specificity
Fungi
Infection
Candidiasis
Yeast
Mycosis
Microbiology
Antibody
Candida
Fungi Imperfecti
Diagnosis
Detection
Thallophyta
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Summary:Sera from 76 immunocompetent and 293 immunocompromised subjects were assayed for anti-Candida antibodies. The sensitivity, specificity, positive predictive value, and negative predictive value for invasive candidiasis were 74%, 75%, 62%, and 84% in the immunocompetent group and 15%, 60%, 1.7%, and 93% in the immunocompromised group, respectively. Syscan3 has high negative predictive value.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Present address: AstraZeneca Pharmaceuticals, Alderly Park, Macclesfield, United Kingdom.
Corresponding author. Mailing address: Laboratory of Mycology Research, Division of Infectious Diseases, University of Texas—Houston Medical School, 6431 Fannin, MSB 2.112, Houston TX 77030. Phone: (713) 500-6733. Fax: (713) 500-5495. E-mail: Luis.Ostrosky-Zeichner@uth.tmc.edu.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.43.9.4834-4835.2005