Glutaminolysis yields a metabolic by-product that stimulates autophagy

Autophagy is an intracellular degradative pathway that plays key roles in the homeostatic turnover of long-lived or damaged proteins and organelles, and in the survival of cells during starvation or other stressful conditions. We have uncovered an unexpected link between glutamine (Gln) metabolism a...

Full description

Saved in:
Bibliographic Details
Published inAutophagy Vol. 6; no. 7; pp. 968 - 970
Main Authors Eng, Christina H., Abraham, Robert T.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.10.2010
Landes Bioscience
Subjects
Ammonia - metabolism
Autophagic Punctum
Autophagy - physiology
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cell Line, Tumor
Culture Media, Conditioned - chemistry
Culture Media, Conditioned - metabolism
Cycle
Glutaminase - metabolism
Glutamine - metabolism
Humans
Landes
Mitochondria - metabolism
Organogenesis
Proteins
Online AccessGet full text

Cover

More Information
Summary:Autophagy is an intracellular degradative pathway that plays key roles in the homeostatic turnover of long-lived or damaged proteins and organelles, and in the survival of cells during starvation or other stressful conditions. We have uncovered an unexpected link between glutamine (Gln) metabolism and the regulation of autophagy. Our findings indicate that ammonia, generated from Gln deamination in mitochondria, functions as an autocrine- and/or paracrine-acting stimulator of autophagic flux.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1554-8627
1554-8635
DOI:10.4161/auto.6.7.13082