Cross-linked β-cyclodextrin and carboxymethyl cellulose hydrogels for controlled drug delivery of acyclovir

• Published in: PloS one Vol. 12; no. 2; p. e0172727
• Main Authors: Malik, Nadia Shamshad, Ahmad, Mahmood, Minhas, Muhammad Usman
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.02.2017; Public Library of Science (PLoS)
• Subjects: Acids; Acrylamide; Acrylic acid; Acyclovir; Acyclovir - administration & dosage; Acyclovir - chemistry; Alternative medicine; Antiviral drugs; beta-Cyclodextrins - chemistry; Carboxymethyl cellulose; Carboxymethylcellulose; Carboxymethylcellulose Sodium - chemistry; Cellulose; Controlled release; Crosslinking; Cyclodextrins; Delayed-Action Preparations; Dielectric properties; Drug delivery; Drug delivery systems; Drug Delivery Systems - methods; Drug development; Drug dosages; Engineering and Technology; Fluid dynamics; Fourier transforms; Free radical polymerization; Free radicals; Hydrogels; Hydrogels - chemistry; Hydrogen-Ion Concentration; Infrared spectroscopy; Kinetics; Medicine and Health Sciences; Morphology; Nonsteroidal anti-inflammatory drugs; pH effects; Pharmaceuticals; Pharmacy; Physical Sciences; Polymerization; Polymers; Polymers - chemistry; Polyvinyl alcohol; Spectroscopy, Fourier Transform Infrared; Thermodynamic properties; β-Cyclodextrin
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0172727

To explore the potential role of polymers in the development of drug-delivery systems, this study investigated the use of β-cyclodextrin (β-CD), carboxymethyl cellulose (CMC), acrylic acid (AA) and N' N'-methylenebis-acrylamide (MBA) in the synthesis of hydrogels for controlled drug delivery of acyclovir (ACV). Different proportions of β-CD, CMC, AA and MBA were blended with each other to fabricate hydrogels via free radical polymerization technique. Fourier transform infrared spectroscopy (FTIR) revealed successful grafting of components into the polymeric network. Thermal and morphological characterization confirmed the formation of thermodynamically stable hydrogels having porous structure. The pH-responsive behaviour of hydrogels has been documented by swelling dynamics and drug release behaviour in simulated gastrointestinal fluids. Drug release kinetics revealed controlled release behaviour of the antiviral drug acyclovir in developed polymeric network. Cross-linked β-cyclodextrin and carboxymethyl cellulose hydrogels can be used as promising candidates for the design and development of controlled drug-delivery systems.