Hyponatremia Associated with Hepatocellular Carcinoma

Hyponatremia is the most common electrolyte abnormality in clinical practice, and a differential diagnosis of the etiologic disorders is crucial because hyponatremia is associated with many different disease states including malignancies. Although only a few cases of hyponatremia with hepatocellular...

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Bibliographic Details
Published inInternal Medicine Vol. 55; no. 8; pp. 961 - 963
Main Authors Ma, Seong Kwon, Kim, Sung Sun, Bae, Eun Hui, Kim, Soo Wan
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.01.2016
Subjects
Aged
arginine vasopressin
Arginine Vasopressin - secretion
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - diagnosis
Diagnosis, Differential
hepatocellular carcinoma
Humans
hyponatremia
Hyponatremia - etiology
Liver Neoplasms - complications
Liver Neoplasms - diagnosis
Male
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Summary:Hyponatremia is the most common electrolyte abnormality in clinical practice, and a differential diagnosis of the etiologic disorders is crucial because hyponatremia is associated with many different disease states including malignancies. Although only a few cases of hyponatremia with hepatocellular carcinoma (HCC) have been previously reported, the abnormal expression of arginine vasopressin (AVP) in tumor cells has not been demonstrated. We herein present a rare case of hyponatremia associated with the aberrant expression of AVP in tumor cells of HCC. This case suggests that an extensive diagnostic work-up is needed in patients with hyponatremia because hyponatremia may provide diagnostic clues for the presence of other underlying disorders.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ObjectType-Report-1
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ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.55.5780