Glucocorticoids and Water Balance: Implications for Hyponatremia Management and Pituitary Surgery

Water balance is fundamental to all homeostasis. The hypothalamic-pituitary-adrenal axis influences water balance through the effects of corticotropin-releasing hormone and cortisol on arginine vasopressin secretion and the peripheral effects of cortisol on hemodynamics and renal water handling. In...

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Bibliographic Details
Published inNeuroendocrinology Vol. 113; no. 8; pp. 785 - 794
Main Authors Castle-Kirszbaum, Mendel, Goldschlager, Tony, Shi, Margaret D Y, Fuller, Peter J
Format Journal Article
LanguageEnglish
Published Basel, Switzerland 01.08.2023
Subjects
Adrenocorticotropic Hormone - metabolism
At the Cutting Edge
Corticotropin-Releasing Hormone - metabolism
Glucocorticoids - pharmacology
Humans
Hydrocortisone - pharmacology
Hyponatremia
Hypothalamo-Hypophyseal System - metabolism
Pituitary-Adrenal System
Hyponatremia
Sodium
Hypernatremia
Pituitary
Cortisol
Syndrome of inappropriate antidiuresis
Glucocorticoid
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Summary:Water balance is fundamental to all homeostasis. The hypothalamic-pituitary-adrenal axis influences water balance through the effects of corticotropin-releasing hormone and cortisol on arginine vasopressin secretion and the peripheral effects of cortisol on hemodynamics and renal water handling. In this review, we explored the complex interplay of glucocorticoids with water balance, with particular attention to hyponatremia and pituitary surgery.
ISSN:0028-3835
1423-0194
DOI:10.1159/000530701