Fenugreek Seed Powder Nullified Aluminium Chloride Induced Memory Loss, Biochemical Changes, Aβ Burden and Apoptosis via Regulating Akt/GSK3β Signaling Pathway

• Published in: PloS one Vol. 11; no. 11; p. e0165955
• Main Authors: Prema, Asokan, Thenmozhi, Arokiasamy Justin, Manivasagam, Thamilarasan, Essa, Musthafa Mohamed, Akbar, Mohammed D, Akbar, Mohammed
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.11.2016; Public Library of Science (PLoS)
• Subjects: Acetylcholinesterase; Acetylcholinesterase - metabolism; AKT protein; Aluminum; Aluminum chloride; Aluminum Compounds - toxicity; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Animal cognition; Animals; Apoptosis; Apoptosis - drug effects; Biochemistry; Biology and Life Sciences; Biotechnology; Chlorides; Chlorides - toxicity; Cognitive ability; Dairy products; Dementia; Dementia disorders; Diabetes; Fenugreek; Food; Food additives; Glycogen Synthase Kinase 3 beta - metabolism; Hyperactivity; Kinases; Learning; Learning - drug effects; Male; Medicinal plants; Medicine and Health Sciences; Memory; Memory Disorders - chemically induced; Memory Disorders - drug therapy; Neurodegenerative diseases; Neurological diseases; Neuroprotection; Neuroprotective Agents - pharmacology; Pathogenesis; Phosphorylation; Physical Sciences; Plant Extracts - pharmacology; Plants, Medicinal - chemistry; Powder; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Rats, Wistar; Research and Analysis Methods; Rodents; Science; Seeds; Signal transduction; Signal Transduction - drug effects; Signaling; Social Sciences; Trigonella; Trigonella foenum-graecum; Weight Loss - drug effects; United States > US; Oman; India
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0165955

Alzheimer's disease (AD) is the most common form of dementia that mainly affects the cognitive functions of the aged populations. Trigonella foenum-graecum (L.) (fenugreek), a traditionally well utilized medicinal plant ubiquitously used as one of the main food additive worldwide, is known to have numerous beneficial health effects. Fenugreek seed extract could be able to inhibit the activity of acetylcholinesterase (AChE), a key enzyme involved in the pathogenesis of AD, and further shown to have anti-parkinsonic effect. The present study was aimed to explore the neuroprotective effect of fenugreek seed powder (FSP) against aluminium chloride (AlCl3) induced experimental AD model. Administration of germinated FSP (2.5, 5 and 10% mixed with ground standard rat feed) protected AlCl3 induced memory and learning impairments, Al overload, AChE hyperactivity, amyloid β (Aβ) burden and apoptosis via activating Akt/GSK3β pathway. Our present data could confirm the neuroprotective effect of fenugreek seeds. Further these results could lead a possible therapeutics for the management of neurodegenerative diseases including AD in future.