Identification of gene expression predictors of occupational benzene exposure

• Published in: PloS one Vol. 13; no. 10; p. e0205427
• Main Authors: Schiffman, Courtney, McHale, Cliona M., Hubbard, Alan E., Zhang, Luoping, Thomas, Reuben, Vermeulen, Roel, Li, Guilan, Shen, Min, Rappaport, Stephen M., Yin, Songnian, Lan, Qing, Smith, Martyn T., Rothman, Nathaniel
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.10.2018; Public Library of Science (PLoS)
• Subjects: Adult; Aquaporins; Area Under Curve; Arsenic; Benzene; Benzene - toxicity; Biochemistry; Bioindicators; Biology and Life Sciences; Biomarkers; Biomarkers - metabolism; Blood; Cancer; Cigarettes; CLEC5A protein; Coenzyme A Ligases - genetics; Deoxyribonucleic acid; Disease control; DNA; DNA methylation; DNA microarrays; Eosinophil Major Basic Protein - genetics; Eosinophil Major Basic Protein - metabolism; Epidemiology; Epigenetics; Exposure; Factories; Female; Gene expression; Gene Expression - drug effects; Gene sequencing; Genes; Genomics; Humans; Hydrocarbons; Immunity; Immunity, Innate - genetics; Inflammation; Innate immunity; Lectins, C-Type - genetics; Lectins, C-Type - metabolism; Leukocytes (mononuclear); Leukocytes - cytology; Male; Medicine and Health Sciences; Mitochondrial DNA; NF-kappa B p50 Subunit - genetics; Nickel; Occupational Exposure; Occupational health; Oligonucleotide Array Sequence Analysis; Peripheral blood mononuclear cells; Physical Sciences; Proteoglycans - genetics; Proteoglycans - metabolism; Public health; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Research and Analysis Methods; RNA, Messenger - metabolism; ROC Curve; Sequence Analysis, RNA; Smoking; Subgroups; Systematic review; Toxicology; Young Adult; Beijing China; California; United States > US; Maryland; China

Previously, using microarrays and mRNA-Sequencing (mRNA-Seq) we found that occupational exposure to a range of benzene levels perturbed gene expression in peripheral blood mononuclear cells. In the current study, we sought to identify gene expression biomarkers predictive of benzene exposure below 1...