How to make a curved Drosophila bristle using straight actin bundles

This, our Inaugural Article as Academy Members, is ironically our swan song from the field of the actin cytoskeleton. By reviewing what we have learned and what we think is going on during development, we hope to lure you, the reader, into applying your skills to the bristle cell. The processes of t...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 102; no. 52; pp. 18785 - 18792
Main Authors Tilney, L.G, DeRosier, D.J
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 27.12.2005
National Acad Sciences
SeriesInaugural Article
Subjects
actin
Actin Cytoskeleton - chemistry
Actins
Actins - chemistry
Animals
binding proteins
Biological Sciences
Curvature
Cytoskeletal Proteins - chemistry
Cytoskeleton
Cytoskeleton - metabolism
Cytoskeleton - ultrastructure
Drosophila
Drosophila melanogaster
Hair
Hair cells
insect development
literature reviews
Microfilament Proteins - chemistry
Microfilaments
Microscopy, Fluorescence
Microvilli
Neural stem cells
Protein Binding
Schwann cells
setae (animal)
Time Factors
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Summary:This, our Inaugural Article as Academy Members, is ironically our swan song from the field of the actin cytoskeleton. By reviewing what we have learned and what we think is going on during development, we hope to lure you, the reader, into applying your skills to the bristle cell. The processes of the assembly and disassembly of actin bundles is laid out in time and space in an organism that lends itself to genetic manipulation. The cell provides every process you could want: filament nucleation, growth of microvilli, joining of microvillar bundles into modules, assembly of modules into bundles, time-dependent use of at least two crossbridging proteins, filament turnover, treadmilling, disassembly, and filament translocation.
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This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected on April 28, 1998, and April 29, 2003.
Author contributions: L.G.T. and D.J.D. wrote the paper.
L.G.T. was elected to the National Academy of Sciences in 1998.
D.J.D. was elected to the National Academy of Sciences in 2003.
Conflict of interest statement: No conflicts declared.
To whom correspondence should be addressed. E-mail: derosier@brandeis.edu.
Contributed by David J. DeRosier, October 31, 2005
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0509437102