Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda

• Published in: Trends in parasitology Vol. 29; no. 8; pp. 394 - 406
• Main Authors: Aksoy, Serap, Caccone, Adalgisa, Galvani, Alison P, Okedi, Loyce M
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2013
• Subjects: African trypanosomiasis; Animals; Biodiversity; DNA, Mitochondrial - genetics; Female; Gastroenterology and Hepatology; Gene Flow; Genetics, Population; Glossina fuscipes; Glossina fuscipes fuscipes; Host-Pathogen Interactions; human African trypanosomiasis; Humans; Infectious Disease; Insect Vectors - genetics; Insect Vectors - parasitology; Insect Vectors - physiology; Male; microbiome; Microbiota; Microsatellite Repeats - genetics; parasitology; Pest Control, Biological - methods; polyandry; population genetics; population structure; sleeping sickness; Symbiosis; Trypanosoma brucei gambiense; Trypanosoma brucei gambiense - physiology; Trypanosoma brucei rhodesiense; Trypanosoma brucei rhodesiense - physiology; Trypanosomiasis, African - epidemiology; Trypanosomiasis, African - parasitology; Trypanosomiasis, African - transmission; Tsetse Flies - genetics; Tsetse Flies - parasitology; Tsetse Flies - physiology; Uganda; Uganda - epidemiology; vector control; Uganda; population genetics; Trypanosoma brucei rhodesiense; Uganda; human African trypanosomiasis; Trypanosoma brucei gambiense; Glossina fuscipes; vector control; sleeping sickness
• ISSN: 1471-4922; 1471-5007
• DOI: 10.1016/j.pt.2013.06.005

Highlights • Population genetics data offer insights with relevance for vector control programs. • Genetic data can help to devise control strategies to prevent reinvasion of target areas. • There are three (northern, southern, and western) genetically distinct clusters of Glossina fuscipes in Uganda. • There is apparent gene flow from southeast to northwest regions of Uganda. • Movement of flies from the southeast towards central Uganda may fuel new HAT foci. • The fly microbiome may influence parasite transmission traits. • Low-density infections with multiple Wolbachia strains are widely prevalent. • There is evidence for a high frequency of multiple matings in females.