Accumulation of Eicosapentaenoic Acid in Membranes of Erythrocytes and Leukocytes during Alterative-Exudative and Allergic Inflammation

• Published in: Bulletin of experimental biology and medicine Vol. 149; no. 5; pp. 583 - 586
• Main Authors: Shilina, N. M, Komarova, O. N, Medvedev, F. A, Dubrovskaya, M. I, Kon', I. Ya
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.10.2010; Springer US; Springer; Springer Nature B.V
• Subjects: Adolescent; Asthma; Asthma - metabolism; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell Membrane - chemistry; Cell Membrane - metabolism; Child; children; docosahexaenoic acid; Docosahexaenoic Acids - metabolism; eicosapentaenoic acid; Eicosapentaenoic Acid - metabolism; Erythrocyte Membrane - chemistry; Erythrocyte Membrane - metabolism; Esophagitis - metabolism; Gastroenteritis - metabolism; Humans; Inflammation; Inflammation - metabolism; Internal Medicine; Laboratory Medicine; Leukocytes - metabolism; membranes of erythrocytes and leukocytes; Obesity - metabolism; Omega-3 fatty acids; Pathology; Peptic Ulcer - metabolism; Unsaturated fatty acids; eicosapentaenoic acid; inflammation; children; membranes of erythrocytes and leukocytes; docosahexaenoic acid
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-010-0998-9

Children patients with alterative-exudative (gastrointestinal diseases) and allergic inflammation (bronchial asthma) exhibited similar changes in fatty acide composition of erythrocyte and leukocyte membranes. They included accumulation of considerable amounts of eicosapentaenoic acid and decrease in the content of docosahexaenoic acid (long-chain derivative of eicosapentaenoic acid). The accumulation of eicosapentaenoic acid and decrease in the content of docosahexaenoic acid in cell membranes probably play a role in the pathogenesis of chronic inflammatory diseases. It is related to a possible decrease in the formation of antiinflammatory eicosanoids (series-5 leukotrienes) and protective compounds (resolvins and protectins) from fatty acids and changes in the physicochemical properties of cell membranes.