Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukemia

• Published in: Blood Vol. 99; no. 1; pp. 375 - 377
• Main Authors: Morison, Ian M., Ellis, Lana M., Teague, Lochie R., Reeve, Anthony E.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.01.2002; The Americain Society of Hematology
• Subjects: Alleles; Biological and medical sciences; Cell Cycle Proteins - genetics; Child; Child, Preschool; Chromosomes, Human, Pair 9; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Female; Gene Deletion; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Hematologic and hematopoietic diseases; Humans; Infant; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Loss of Heterozygosity; Medical sciences; Mothers; Mutation; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Sequence Analysis, DNA; Tumor Suppressor Proteins; Chromosomal aberration; Human; Maternal origin; Pathogenesis; Acute; Malignant hemopathy; Chromosome C9; Abnormal chromosome C9; Lymphoproliferative syndrome; Germ line; Loss of heterozygosity; Deletion; Abnormal chromosome; Genetics; Acute lymphocytic leukemia; Child
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.V99.1.375

Germ-line events, such as paternal mutation or genomic imprinting, contribute to the early onset of childhood cancers such as retinoblastoma, Wilms tumors, and neuroblastoma. Given the high frequency of deletion involving chromosome 9p in childhood acute lymphoblastic leukemia (ALL), this study investigated whether 9p deletion might reflect preexisting germ-line gene inactivation. To do this the parental origin of deletion was determined in 10 cases of ALL with 9p21 loss of heterozygosity. Of these cases, 9 showed loss of the maternally derived allele, suggesting that a germ-line event involving a 9p gene may play a role in the onset of childhood ALL.